Dual monitor setup freeze

I have 2 monitors, one 1440p 180hz and the other 1080p 60hz (in portrait mode) and if I leave the computer for a few minutes sometimes when I get back one of the monitors output is frozen, and eventually the other one will freeze as well. I don’t know how to tell where the problem is or even if it’s possible to fix

Signed up to second this. Main monitor is 1440p 165hz, secondary is 1080p 60hz, running an Nvidia 2080 Super on KDE (might switch to gnome to see if it fixes it) and I’ll randomly have my secondary monitor freeze. If I remove the display from settings it causes primary to completely freeze but I must reboot to resolve.

Audio still plays during this.